A short while ago I picked up the updated edition of the Rogue Space RPG.
Mass Effect conversion for the game. If your looking for a fast and easy to learn RPG for your Sci Fi fix I recommend Rogue Space, now mind you it is very rules-lite so if your into Pathfinder type crunchy stuff, this may not be your cup of Joe, but for my old bones and limited time this is a pretty sweet little set of rules. It seems perfect for pick up games, Con games but I can see it being useable for longer play as well. I would like to have seen some more options for creating alien races, but the rules are lite enough that you can do your own with minimal fuss. Check out Mik's blog for examples of how the Mass Effect Aliens look via the Rogue Space rules.
For another review of this game check out my buddy Giles blog over HERE!
Good Gaming -B